At a Glance:

  • 2024 Fluoride increases neurobehavioral problems in Los Angeles children.
  • 2024 Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies.
  • 2023 Fluoridation increases behaviours associated with ADHD, autism spectrum disorder. (ASD), intellectual disability, and specific learning disorders.
  • 2023 Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.
  • 2022 Iodine status of mother affects boys Intelligence.
  • 2022 Adolescents with elevated urinary fluoride concentrations exhibit more somatization.
  • 2021 Critical windows of fluoride neurotoxicity in Canadian children.
  • 2021 Higher fluoride intake from foods and beverages during pregnancy is associated with lower cognitive neurodevelopment in male offspring.
  • 2020 Babies fed infant formula using fluoridated water have significantly lowered IQ.
  • 2019 Maternal fluoride exposure during pregnancy associated with a 3 fold increase in ADHD diagnoses in Canadian offspring.
  • 2019 Maternal fluoride exposure during pregnancy associated with lowered IQ Scores in Canadian offspring.
  • 2019 Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents.
  • 2019 Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents.
  • 2019 Fluoride inhibits one of our most important enzymes..
  • 2019 Fluoride contributes to impaired iodine absorption
  • 2019 Fluoride linked to eye disease.
  • 2019 World leading expert on lead warns of fluoride toxicity
  • 2018 NIH Study. Lower IQ in children aged 1 -3 years.
  • 2018 NIH Study. Pre-natal fluoride exposure linked to ADHD in Mexican children.
  • 2017 NIH study. Pre-natal fluoride exposure linked to lowered IQ in Mexican children.
  • 2015 Fluoridation associated with higher rates of hypothyroidism in the UK.
  • 2015 Fluoridation linked to ADHD in US adolescents.

A Bit More Detail:

2024 Maternal Urinary Fluoride and Child Neurobehavior at Age 36 Months.

Malin et al. “In this prospective cohort study of mother-child pairs in Los Angeles, California, prenatal fluoride exposure was associated with increased neurobehavioral problems. These findings suggest that there may be a need to establish recommendations for limiting fluoride exposure during the prenatal period.” – NIH study.

2024 Dose dependence of prenatal fluoride exposure associations with cognitive performance at school age in three prospective studies.

Data collected from a prospective Odense Child Cohort (OCC) with results from two previous birth cohort studies from Mexico and Canada to characterize the dose-effect relationship in greater detail. A Bench Mark Confidence Level (BMCL) was found to be 0.28 mg/L of urine-fluoride.

2023 Dewey et al. Fluoride exposure during pregnancy from a community water supply is associated with executive function in preschool children: A prospective ecological cohort study.

Study from Calgary where fluoridation stopped in 2011. Study published in Science of the Total Environment. Found “poorer inhibitory control and cognitive flexibility” in children born when mothers consumed fluoridation.  The authors said their tests measured “executive function deficits [that have been] consistently associated with behavioural and neurodevelopmental disorders such as ADHD, autism spectrum disorder (ASD), intellectual disability, and specific learning disorders”.

2023 Hall et atFluoride exposure and hypothyroidism in a Canadian pregnancy cohort.

Study from Canada. Found that an increase in drinking water fluoride concentration increased the chance of hypothyroidism. Children born to women with hypothyroidism had lowered IQ – NIH study.

2022 Goodman et al. Iodine Status Modifies the Association between Fluoride Exposure in Pregnancy and Preschool Boys’ Intelligence.
Canadian study. Found that boys whose mothers had low iodine levels while pregnant lost, on average, 9.3 IQ points, while those of mothers with adequate iodine lost 5.9 IQ points, for every 1 mg/g increase in mother’s urine fluoride concentration. – NIH study.

2022 Adkins Fluoride exposure during early adolescence and its association with internalizing symptoms.

Study evaluated the relationship between urinary fluoride and early adolescent internalizing symptoms in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS). Found Adolescents with elevated urinary fluoride concentrations exhibit more somatization symptoms. Males may represent an at-risk population for fluoride-related internalizing behaviors – NIH study.

2021 Farmus et al. Critical windows of fluoride neurotoxicity in Canadian children.

Published in Environmental Research. “Within sex, the association between fluoride and PIQ significantly differed across the three exposure windows (boys: p = .01; girls: p = .01); among boys, the strongest association was during the prenatal window, B = -3.01, 95% CI: -4.60, -1.42, whereas among girls, the strongest association was during infancy, B = -2.71, 95% CI: -4.59, -0.83″.

2021 Cantoral Dietary fluoride intake during pregnancy and neurodevelopment in toddlers: A prospective study in the progress cohort.

Mexican study where fluoride is added to salt. Medium fluoride intake was 1 mg/day. Higher fluoride intake from foods and beverages during pregnancy is associated with lower cognitive neurodevelopment in male offspring – NIH study.

2020 Till et al. Fluoride exposure from infant formula and child IQ in a Canadian birth cohort.
Published in Environment International. Found that for every 1 mg/L increase in tap water fluoride there was a 9 IQ point decrease in the formula-fed infants but almost no decrease in exclusively breastfed infants.  Breastmilk is highly protective against fluoride exposure to the baby because concentrations of fluoride in breastmilk are at least 100 times lower than in formula made from fluoridated water – NIH study.

2019 Riddell et al. Association of water fluoride and urinary fluoride concentrations with attention deficit hyperactivity disorder in Canadian youth.

Published in Environment International. Found a strong association between fluoride exposure and diagnoses of ADHD in a Canadian sample that is representative of the entire country. Sourced from a survey that is Canada’s equivalent to NHANES in the US.  Adolescents living in fluoridated places had a 3-fold greater odds of being diagnosed with ADHD as those in non-fluoridated areas.  This finding suggests that fluoridated water may cause the majority of all ADHD cases.

2019 Green et al. Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada.

2019 Green et al August Published in the prestigious JAMA Pediatrics this study looks at fluoride urine levels and fluoride exposure in pregnant Canadian women. It finds fluoride exposure from fluoridated water is significantly associated with lowered IQ in their offspring – NIH study. 

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2019 Malin et al. Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016.

Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents.

2019 Declan Waugh. Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

Fluoride Inhibits a Crucial Enzyme. Loss of this enzyme activity is implicated in neurodevelopmental, neuropsychiatric and neurodegenerative.

2018 OP V – 2 Prenatal fluoride exposure and neurobehavior among children 1–3 years of age in Mexico.

Adds to recently published report on prenatal fluoride and cognition at ages 4 and 6–12 years by suggesting that higher in utero exposure to F has an adverse impact on offspring cognitive development that can be detected earlier, in the first three years of life. – NIH Study.

2018 Bashash et al. Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6–12 years of age in Mexico City.

Higher concentration of maternal urinary fluoride was associated with more ADHD-like symptoms in school-age children. Prenatal exposure to fluoride was most strongly associated with behavioral ratings of inattention, but not hyperactivity and impulse control.

Findings are consistent with the growing body of evidence suggesting neurotoxicity of early-life exposure to fluoride. – NIH study.

 

2017 Bashash et al. Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age in Mexico.

Pre-natal fluoride exposure linked to lowered IQ. This study measured the fluoride urine levels of pregnant mothers and found every 1 mg/L increase in fluoride was associated with a 5 IQ point drop in their offspring. The fluoride urine levels were the same as levels found in pregnant New Zealand women – NIH study.

 

Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association.

2015 US Study finding higher rates of ADHD published in fluoridated US states. Published in Environmental Health.